1H-Cycloprop[e]azulen-4-ol, 1a,2,3,4,6,7,7a,7b-octahydro-1,1,4,7-tetramethyl-, (1aR,4S,7R,7aS,7bR)- synthesis

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 80 percent / KOtBu / dimethylsulfoxide / 100 °C
2: 96 percent / oxone; NaHCO₃; 18-crown-6 / CH₂Cl₂; H₂O; acetone / 2 h / 0 °C
3: 57 percent / diethylamine; n-butyllithium / diethyl ether; hexane / 0 - 20 °C

References:

Moreno-Dorado, F. Javier;Lamers, Yvonne M. A. W.;Mironov, Grigore;Wijnberg, Joannes B. P. A.;De Groot, Aede [Tetrahedron,2003,vol. 59,# 39,p. 7743 - 7750]