1-(4-chloro-phenyl)-4,4-dimethyl-2-[1,2,4]triazol-1-yl-pentan-3-one synthesis
- Product Name:1-(4-chloro-phenyl)-4,4-dimethyl-2-[1,2,4]triazol-1-yl-pentan-3-one
- CAS Number:63190-87-4
- Molecular formula:C15H18ClN3O
- Molecular Weight:291.78
Yield: 93.8%
Reaction Conditions:
with potassium hydroxide in isopropyl alcohol at 75 - 80; for 4 h;Solvent;Reagent/catalyst;
Steps:
1-5
Add 50 grams of 3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one in a round bottom flask, add 150 grams of isopropanol, 15 grams of KOH, 5 grams of polyethylene glycol 400, and stir below 75°C, add 72.3 g of p-chlorobenzyl chloride dropwise, and keep it at 80°C for 4h after the dropping, when the reaction is complete, stop the reaction, wash and layer to obtain 145 grams of wastewater, suction filtration of crystals to obtain 1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pentan-3-one: 82.0 grams, yield 93.8%, content> 95%, the filtrate was concentrated to obtain 13 grams of waste liquid.
References:
Jiangsu Qi Zhou Green Chemical Co., Ltd.;Jiangsu Qi Zhou Green Science And Technology Institute Co., Ltd.;Zhu Min;Zhang Hu;Liu Pengfei;An Jing;Liu Yuchao CN111777565, 2020, A Location in patent:Paragraph 0021; 0025-0026; 0027-0028; 0029-0030; 0031-0034
5469-26-1
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63190-87-4
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