MORPHOLIN-4-YL-PIPERIDIN-4-YL-METHANONE HYDROCHLORIDE synthesis
- Product Name:MORPHOLIN-4-YL-PIPERIDIN-4-YL-METHANONE HYDROCHLORIDE
- CAS Number:63214-57-3
- Molecular formula:C10H18N2O2
- Molecular Weight:198.26
757949-38-5
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63214-57-3
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Yield:63214-57-3 400 mg
Reaction Conditions:
with hydrogenchloride in methanol at 20; for 3 h;Temperature;
Steps:
57.2 Step 2: Preparation of piperidin- 1-yI(piperidin-4-yI)methanone
To a stirred solution of tert-butyl 4-(piperidine-i -carbonyl)piperidine-i -carboxylate (500 mg, 1 .69 mmol) in methanol (5 mL) was added 4N methanolic hydrogen chloride solution (15 mL). The mixture wasstirred at 20 °C for 16 h. The reaction mixture was concentrated under reduced pressure to provide piperidin-1-yl(piperidin-4-yl)methanone (400 mg) as a colorless oil. 1H NMR (400 MHz, DMSO-d6) O 3.51- 3.36 (m, 4H), 3.28-3.18 (m, 2H), 2.90 (s, 4H), 1 .82-1 .68 (m, 4H), 1 .64-1 .37 (m, 6H).
References:
WO2018/81167,2018,A1 Location in patent:Page/Page column 98; 99; 157; 158
84358-13-4
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63214-57-3
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