ChemicalBook CAS DataBase List 2-(N-acetylacetamido)-3-(4-hydroxy-3-methoxyphenyl)propanoic acid

2-(N-acetylacetamido)-3-(4-hydroxy-3-methoxyphenyl)propanoic acid synthesis

5synthesis methods

Product Name:2-(N-acetylacetamido)-3-(4-hydroxy-3-methoxyphenyl)propanoic acid
CAS Number:63357-45-9
Molecular formula:C12H15NO5
Molecular Weight:253.25

Benzene, 4-(bromomethyl)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methoxy-

113931-97-8
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2-(N-acetylacetamido)-3-(4-hydroxy-3-methoxyphenyl)propanoic acid

63357-45-9
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Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere
1.2: 4 h / 0 °C / Inert atmosphere
2.1: potassium hydroxide / water; ethanol / 3 h / Inert atmosphere; Reflux
3.1: hydrogenchloride / water / 6 h / Reflux

References:

Schneider, Tobias;Kubyshkin, Vladimir;Budisa, Nediljko [European Journal of Organic Chemistry,2018,vol. 2018,# 18,p. 2053 - 2063]