Benzamide, 5-chloro-N-(2,4-difluorophenyl)-2-hydroxy- synthesis
- Product Name:Benzamide, 5-chloro-N-(2,4-difluorophenyl)-2-hydroxy-
- CAS Number:634189-17-6
- Molecular formula:C13H8ClF2NO2
- Molecular Weight:283.66
Yield:634189-17-6 12%
Reaction Conditions:
with pyridine;phosphorus trichloride in toluene; for 12 h;Inert atmosphere;Reflux;
Steps:
59 4.1.1 Procedure A
General procedure: The salicylic acid (1.2 equiv) was added to a mixture of toluene (0.3 M), aniline (1.0 equiv), phosphorus trichloride (1.1 equiv), and pyridine (0.05 equiv) in a Radley’s Carousel reaction tube (modified from Itai et al.20). The mixture was refluxed under nitrogen for 12 h then cooled to room temperature. Aqueous sodium bicarbonate was added dropwise to attain pH 6-7. The resultant mixture was extracted with EtOAc. The organic extracts were combined, dried (MgSO4), and concentrated under vacuum. After chromatography (1:10 EtOAc:Hex) compounds were recrystallized (EtOAc/Hex).
References:
Lee, Ill-Young;Gruber, Todd D.;Samuels, Amanda;Yun, Minhan;Nam, Bora;Kang, Minseo;Crowley, Kathryn;Winterroth, Benjamin;Boshoff, Helena I.;Barry III, Clifton E. [Bioorganic and Medicinal Chemistry,2013,vol. 21,# 1,p. 114 - 126]
321-14-2
376 suppliers
$15.00/25g
634189-17-6
0 suppliers
inquiry