2-methoxy-N-[2-nitro-5-(phenylthio)phenyl]acetamide synthesis
- Product Name:2-methoxy-N-[2-nitro-5-(phenylthio)phenyl]acetamide
- CAS Number:63470-85-9
- Molecular formula:C15H14N2O4S
- Molecular Weight:318.35
Yield:63470-85-9 95.5%
Reaction Conditions:
at 120 - 130;Temperature;
Steps:
1.2; 2.2; 3.2; 4.2; 5.2; 6.2 (2) Preparation of 2-nitro-5-phenylsulfanyl-(2-methoxy)acetanilide:
(2) Preparation of 2-nitro-5-phenylsulfanyl-(2-methoxy)acetanilide: equipped with thermometer, condenser and stirring Add 2-nitro-5-phenylthioaniline (24.7g) and methyl 2-methoxyacetate (123.0g) into the 500ml reaction flask of the device. Replace with nitrogen three times, stir and heat up to 120-130°C for 5-7 hours; Cool down to below 70°C, add n-hexane dropwise (200ml) and then cooled to 0~5°C, continue to stir for 1 hour, filter, collect the precipitated crystals, wash and dry to obtain 2-nitro-5- Phenylthio-(2-methoxy)acetanilide, the yield is 95.5%;
References:
CN108299259,2018,A Location in patent:Page/Page column 5-7
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