tert-butyl 7,7-diMethyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate synthesis

2synthesis methods

Product Name:tert-butyl 7,7-diMethyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate
CAS Number:635712-88-8
Molecular formula:C13H21N3O2
Molecular Weight:251.32

1-Piperidinecarboxylic acid, 5-[(dimethylamino)methylene]-3,3-dimethyl-4-oxo-, 1,1-dimethylethyl ester, (5E)-

943145-90-2
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tert-butyl 7,7-diMethyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate

635712-88-8
44 suppliers
$175.00/250mg

Yield:635712-88-8 94%

Reaction Conditions:

with hydrazine in methanol at 20;

Steps:

To a solution [OF 5-DIMETHYLAMINOMETHYLENE-3, 3-DIMETHYL-4-OXO-PIPERIDINE-1-] carboxylic acid [TERT-BUTYL] ester (6.35 g, 22 mmol) in methanol (15 mL) was added hydrazine hydrate (1.2 mL, 1.1 equiv). The solution was stirred at room temperature overnight-and concentrated-to give [5. 3- G (94%) WHICH-WAS] used without purification. Mass spec.: 252.19 [(MH) +.]

References:

WO2003/104236,2003,A1 Location in patent:Page 159

1-Piperidinecarboxylic acid, 5-[(dimethylamino)methylene]-3,3-dimethyl-4-oxo-, 1,1-dimethylethyl ester, (5Z)-

1028320-14-0
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635712-88-8
44 suppliers
$175.00/250mg

References