4-chloro-N-methyl-3-nitro-N-phenylbenzenesulphonamide synthesis

Yield:6409-51-4 61%

Reaction Conditions:

with triethylamine in toluene at 70 - 80; for 1 h;

Steps:

5.2

4-Chloro-3-nitrobenzene-1-sulfonyl chloride (10.6 g, 0.041 mol) was dissolved in toluene (50 ml); and triethylamine (4.14 g, 0.041 mol) was then added. To the resulting solution, N-methylaniline (4.4 g, 0.041 mol) was added under stirring. The reaction mixture was incubated at 70-80° C. for 1 h. Thereafter, it was allowed to cool. The cooled solution was washed twice with 30 ml of water and concentrated under vacuum. The residue was recrystallized from ethanol. The yield of 4-chloro-N-methyl-3-nitro-N-phenylbenzene sulfonamide was 9.4 g (61%).

References:

US2011/3826,2011,A1 Location in patent:Page/Page column 10