ChemicalBook CAS DataBase List 3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)aniline

3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)aniline synthesis

7synthesis methods

Product Name:3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)aniline
CAS Number:641571-21-3
Molecular formula:C12H16F3N3
Molecular Weight:259.28

Piperazine, 1-methyl-4-[3-nitro-5-(trifluoromethyl)phenyl]-

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3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)aniline

641571-21-3
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$168.00/250mg

Yield:641571-21-3 42 %

Reaction Conditions:

with ethanol;water;iron;acetic acid at 80;

Steps:

3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)aniline (7 g).

General procedure: Compound 6a (0.79 g, 2.9 mmol) together with Fe powder (0.65 g, 11.6mmol) was dissolved in 95 % ethanol (40 mL) containing 8.8 mL AcOH.The mixture was stirred for 2 h at 80 C and then concentrated. Theresidue was added with saturated sodium carbonate to adjust the pH to8.0-9.0, and the solution was extracted with ethyl acetate (50 mL × 3).The organic layers were dried over Na2SO4, filtered, and concentrated.The crude material was purified via silica flash chromatography (PE/EA60:40) to give compound 7a cream-colored solid (0.60 g, 85 %).

References:

Yang, Zichao;Ai, Yangcheng;Wan, Shanhe;Yang, Zilong;Li, Honghao;Li, Zhonghuang;Huang, Chunhui;Zhang, Lishun;Li, Mingxia;Zhang, Jiajie;Zhang, Tingting [Bioorganic and Medicinal Chemistry,2022,vol. 74,art. no. 117069]

109-01-3 Synthesis