5'-Bromo-1',2'-Dihydrospiro[Cyclohexane-1,3'-Indole] synthesis
1synthesis methods
- Product Name:5'-Bromo-1',2'-Dihydrospiro[Cyclohexane-1,3'-Indole]
- CAS Number:645416-98-4
- Molecular formula:C13H16BrN
- Molecular Weight:266.18
Yield:645416-98-4 50%
Reaction Conditions:
Stage #1: 4-bromophenylhydrazine hydrochloridewith trifluoroacetic acid in toluene;acetonitrile at 35;
Stage #2: cyclohexanecarbaldehyde in toluene;acetonitrile at 20 - 35; for 8 h;
Stage #3: with methanol;sodium tetrahydroborate in toluene;acetonitrile at -10 - 0; for 1.5 h;
References:
WO2004/5253,2004,A1 Location in patent:Page/Page column 57; 58