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4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol synthesis

13synthesis methods
-

Yield:649735-41-1 86%

Reaction Conditions:

with ammonium formate;palladium on activated charcoal in N,N-dimethyl-formamide at 20; for 1.5 h;

References:

Bhide, Rajeev S.;Cai, Zhen-Wei;Zhang, Yong-Zheng;Qian, Ligang;Wei, Donna;Barbosa, Stephanie;Lombarde, Louis J.;Borzilleri, Robert M.;Zheng, Xiaoping;Wu, Laurence I.;Barrish, Joel C.;Kim, Soong-Hoon;Leavitt, Kenneth;Mathur, Arvind;Leith, Leslie;Chao, Sam;Wautlet, Barri;Mortillo, Steven;Jeyaseelan Sr., Robert;Kukral, Daniel;Hunt, John T.;Kamath, Amrita;Fura, Aberra;Vyas, Viral;Marathe, Punit;D'Arienzo, Celia;Derbin, George;Fargnoli, Joseph [Journal of Medicinal Chemistry,2006,vol. 49,# 7,p. 2143 - 2146]