2,8-Dibromo-4-(trifluoromethyl)quinoline-3-carboxylic acid synthesis

4synthesis methods

Product Name:2,8-Dibromo-4-(trifluoromethyl)quinoline-3-carboxylic acid
CAS Number:663193-43-9
Molecular formula:C11H4Br2F3NO2
Molecular Weight:398.96

615-36-1
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2,8-Dibromo-4-(trifluoromethyl)quinoline-3-carboxylic acid

663193-43-9
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Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: 44 percent / H₂O / 6 h / 130 °C
2.1: 22 percent / H₂SO₄ (96 percent) / 0.83 h / 90 °C
3.1: 59 percent / POBr₃ / 2 h / 150 °C
4.1: (iPr)2NH; BuLi / hexane; tetrahydrofuran / 2 h / -75 °C
4.2: 81 percent / tetrahydrofuran; hexane / -78 °C

References:

Marull, Marc;Lefebvre, Olivier;Schlosser, Manfred [European Journal of Organic Chemistry,2004,# 1,p. 54 - 63]

124-38-9
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Quinoline, 2,8-dibromo-4-(trifluoromethyl)-

663192-94-7
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663193-43-9
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References

8-bromo-4-(trifluoromethyl)-1H-quinolin-2-one

663192-71-0
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References

N-(2-bromophenyl)-4,4,4-trifluoro-3-oxobutanamide

663192-17-4
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663193-43-9
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References