![](/CAS/GIF/663619-90-7.gif)
4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl- synthesis
- Product Name:4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl-
- CAS Number:663619-90-7
- Molecular formula:C9H7BrN2O2
- Molecular Weight:255.07
![2-Amino-3-bromo-5-methylpyridine](/CAS/GIF/17282-00-7.gif)
17282-00-7
324 suppliers
$5.00/1g
![Malonyl chloride](/CAS/GIF/1663-67-8.gif)
1663-67-8
213 suppliers
$36.79/5g
![4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl-](/CAS/GIF/663619-90-7.gif)
663619-90-7
45 suppliers
$68.00/100mg
Yield:663619-90-7 88%
Reaction Conditions:
in dichloromethane at 0 - 20; for 48 h;
Steps:
9-Bromo-2-hydroxy-7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (1)
To a solution of 2-amino-3-bromo-5-methylpyridine (2.25 g, 12 mmol) in CH2Cl2 (25 mL) was added malonyldichloride (1.25 mL, 12.5 mmol) at 0 C. The mixture was stirred at room temperature for 48 h. The yellow solid was collected by filtration, washed with CH2Cl2 (325 mL), and dried under reduced pressure. Compound 1 was obtained as a yellow solid with a yield of 88% (2.75 g). M.p. 209 - 211 C. - 1H NMR ([D6]DMSO, 400 MHz): d = 8.74 (s, 1H, 8-CH), 8.29 (s, 1H, 6-CH), 5.55 (s, 1H, 3-CH), 2.35(s, 3H, 7-CH3) ppm. - HRMS ((+)-ESI): m=z = 254:9793 (calcd. 254.9769 for C9H8BrN2O2, [M+H]+).
References:
Liu, Chunjing;Li, Benyi;Mitscher, Lester [Zeitschrift fur Naturforschung, B: Chemical Sciences,2014,vol. 69,# 7,p. 817 - 822]
![MALONIC ACID BIS(2,4,6-TRICHLOROPHENYL) ESTER](/CAS/GIF/15781-70-1.gif)
15781-70-1
113 suppliers
$5.00/100mg
![2-Amino-3-bromo-5-methylpyridine](/CAS/GIF/17282-00-7.gif)
17282-00-7
324 suppliers
$5.00/1g
![4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl-](/CAS/GIF/663619-90-7.gif)
663619-90-7
45 suppliers
$68.00/100mg
![2-Amino-5-methylpyridine](/CAS/GIF/1603-41-4.gif)
1603-41-4
536 suppliers
$7.00/25g
![4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl-](/CAS/GIF/663619-90-7.gif)
663619-90-7
45 suppliers
$68.00/100mg
![2-Amino-3-bromo-5-methylpyridine](/CAS/GIF/17282-00-7.gif)
17282-00-7
324 suppliers
$5.00/1g
![Diethyl malonate](/CAS/GIF/105-53-3.gif)
105-53-3
737 suppliers
$5.00/25g
![4H-Pyrido[1,2-a]pyrimidin-4-one, 9-bromo-2-hydroxy-7-methyl-](/CAS/GIF/663619-90-7.gif)
663619-90-7
45 suppliers
$68.00/100mg