ChemicalBook CAS DataBase List Cyclopropanecarboxylic acid, 1-[(trifluoroacetyl)amino]- (9CI)

Cyclopropanecarboxylic acid, 1-[(trifluoroacetyl)amino]- (9CI) synthesis

4synthesis methods

Product Name:Cyclopropanecarboxylic acid, 1-[(trifluoroacetyl)amino]- (9CI)
CAS Number:669066-98-2
Molecular formula:C6H6F3NO3
Molecular Weight:197.11

383-63-1 Synthesis

383-63-1
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$10.00/25g

22059-21-8 Synthesis

22059-21-8
439 suppliers
$14.00/1g

Cyclopropanecarboxylic acid, 1-[(trifluoroacetyl)amino]- (9CI)

669066-98-2
18 suppliers
$45.00/10mg

Yield:669066-98-2 87%

Reaction Conditions:

with triethylamine in methanol at 20; for 24 h;Inert atmosphere;

Steps:

A-1.A

ΓΑ1 l-(2,2,2-Trifluoro-acetylamino)-cyclopropanecarboxylic acid1-Amino-cyclopropanecarboxylic acid (2.483 g, 23.8 mmol) was added to MeOH (60 ml) to give a white suspension. Et₃N (2.65 g, 3.65 ml, 26.2 mmol) and trifluoro-acetic acid ethyl ester (3.72 g, 3.12 ml, 26.2 mmol) were added and the mixture was stirred at RT. After 24 h, it was poured onto ice, acidified with IN HCl and extracted four times with EtOAc. The organic layer was washed once with water and once with IN HCl, dried over MgS0₄, filtered and evaporated; the residue formed was dried in vacuo to give the title compound (4.07 g, 87%) as colorless solid. MS: 196.0 (M-H^~).

References:

WO2012/101011,2012,A2 Location in patent:Page/Page column 44

383-63-1 Synthesis

383-63-1
479 suppliers
$10.00/25g

68781-13-5 Synthesis