5-Methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid synthesis
- Product Name:5-Methyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid
- CAS Number:66909-27-1
- Molecular formula:C7H7NO3
- Molecular Weight:153.14
124-38-9
122 suppliers
$214.00/14L
89488-30-2
235 suppliers
$7.00/1g
66909-27-1
57 suppliers
$45.00/10mg
Yield:66909-27-1 61%
Reaction Conditions:
Stage #1: 5-bromo-3-methylpyridin-2(1H)-onewith n-butyllithium in tetrahydrofuran;hexane at -78; for 0.5 h;
Stage #2: carbon dioxide in tetrahydrofuran;hexane at -78 - 20;
Stage #3: with hydrogenchloride;water
References:
Ando, Makoto;Sato, Nagaaki;Nagase, Tsuyoshi;Nagai, Keita;Ishikawa, Shiho;Takahashi, Hirobumi;Ohtake, Norikazu;Ito, Junko;Hirayama, Mioko;Mitobe, Yuko;Iwaasa, Hisashi;Gomori, Akira;Matsushita, Hiroko;Tadano, Kiyoshi;Fujino, Naoko;Tanaka, Sachiko;Ohe, Tomoyuki;Ishihara, Akane;Kanatani, Akio;Fukami, Takehiro [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 16,p. 6106 - 6122] Location in patent:experimental part