2,5-Methanopentalene-3a(1H)-carbonyl chloride, hexahydro- (9CI) synthesis

Yield:67064-09-9 99%

Reaction Conditions:

with oxalyl dichloride in dichloromethane;

Steps:

14.A

To a solution of commercially available hexahydro-2,5-methano-pentalene- 3?-carboxylic acid (10 g, 0 06 mol) in dichloromeihane (200 mL) was added oxalyl chloride (8 7 g, 0 066 mol) The mixture was stirred overnight and then concentrated under reduced pressure to afford the title compound as a colorless oil (1 1 g, 99%). MS (DCI/NH3) m/z 184 (M+H)^H

References:

WO2007/140439,2007,A2 Location in patent:Page/Page column 40