1H-Benzimidazole,4-methyl-2-(trifluoromethyl)-(9CI) synthesis
1synthesis methods
- Product Name:1H-Benzimidazole,4-methyl-2-(trifluoromethyl)-(9CI)
- CAS Number:6742-83-2
- Molecular formula:C9H7F3N2
- Molecular Weight:200.16
Yield:6742-83-2 99%
Reaction Conditions:
at 70; for 16 h;
Steps:
2. General Procedure A
General procedure: In a screw-cap vial, the diamine or aminothiophenol (1 mmol) was dissolved in fluorinated carboxylic acid (2 mL, 0.5 M) and the reaction was stirred at 70 °C for 16 hours. The fluorinated carboxylic acid was then evaporated under reduced pressure and the crude product was purified by silica gel column chromatography to yield the corresponding product.
References:
René, Olivier;Souverneva, Alexandra;Magnuson, Steven R.;Fauber, Benjamin P. [Tetrahedron Letters,2013,vol. 54,# 3,p. 201 - 204] Location in patent:supporting information