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1,9-Dihydroxy-3,7-dioxanonane, 2,2μ-(Trimethylenedioxy)diethanol synthesis
- Product Name:1,9-Dihydroxy-3,7-dioxanonane, 2,2μ-(Trimethylenedioxy)diethanol
- CAS Number:67439-82-1
- Molecular formula:C7H16O4
- Molecular Weight:164.2
![Acetic acid, 2,2'-[1,3-propanediylbis(oxy)]bis-, diethyl ester (9CI)](/CAS/20210111/GIF/77319-28-9.gif)
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![1,9-Dihydroxy-3,7-dioxanonane, 2,2μ-(Trimethylenedioxy)diethanol](/CAS/GIF/67439-82-1.gif)
67439-82-1
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Yield: 90%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at 0 - 10; for 1 h;
Steps:
2 Step 2-2-[3-(2-Hydroxyethoxy)propoxy]ethanol
To a solution of ethyl 2-[3-(2-ethoxy-2-oxo-ethoxy)propoxy]acetate (20.0 g, 80.5 mmol) in THF (300 mL) was added LiAlH4 (6.24 g, 161 mmol, 98% purity) at 0° C. The mixture was then stirred at 10° C. for 1 hour. On completion, the mixture was quenched with water (10 mL) and NaOH aqueous solution (15%, 10 mL) at 0° C., and the reaction was filtered. The filtrate was dried over Na2SO4, filtered and concentrated in vacuo to give the title compound (12 g, 90% yield) as colourless oil. 1H NMR (400 MHz, DMSO-d6) δ 4.53 (t, J=5.2 Hz, 2H), 3.50-3.45 (m, 4H), 3.43 (t, J=6.4 Hz, 4H), 3.37 (t, J=5.2 Hz 4H), 1.75-1.68 (m, 2H)
References:
Kymera Therapeutics, Inc.;Mainolfi, Nello;Ji, Nan;Kluge, Arthur F.;Weiss, Matthew M.;Zhang, Yi US2019/192668, 2019, A1 Location in patent:Paragraph 3132; 3134
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![1,9-Dihydroxy-3,7-dioxanonane, 2,2μ-(Trimethylenedioxy)diethanol](/CAS/GIF/67439-82-1.gif)
67439-82-1
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$88.40/250mg
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![1,9-Dihydroxy-3,7-dioxanonane, 2,2μ-(Trimethylenedioxy)diethanol](/CAS/GIF/67439-82-1.gif)
67439-82-1
20 suppliers
$88.40/250mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
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![1,9-Dihydroxy-3,7-dioxanonane, 2,2μ-(Trimethylenedioxy)diethanol](/CAS/GIF/67439-82-1.gif)
67439-82-1
20 suppliers
$88.40/250mg
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![1,9-Dihydroxy-3,7-dioxanonane, 2,2μ-(Trimethylenedioxy)diethanol](/CAS/GIF/67439-82-1.gif)
67439-82-1
20 suppliers
$88.40/250mg