2-BroMo-N-[4-chloro-2-(4-hydroxybenzoyl)phenyl]acetaMide synthesis

Yield:-

Reaction Conditions:

with sodium carbonate in water;

Steps:

9 2-Bromo-4'-chloro-2'-(4-hydroxybenzoyl)acetanilide

EXAMPLE 9 2-Bromo-4'-chloro-2'-(4-hydroxybenzoyl)acetanilide A solution of 41 g (0.165 mole) 2-amino-5-chloro-4'-hydroxybenzophenone in 800 ml of ether and 200 ml of water was cooled to 5°. The mixture was stirred while 20 ml (0.277 mole) of bromoacetyl bromide and a 20% solution of sodium carbonate were added alternately keeping the solution slightly basic. After 20 min. the reaction mixture was filtered to collect 60 g (about 100%) of product mp 201°-202°. Recrystallization from ethanol gave colorless prisms, mp 201°-203°. Anal.-Calc. for C₁₅ H₁₁ BrClNO₃: C, 48.87; H, 3.01, Tot. hal., 31.30. Found: C, 49.17; H, 3.34; Tot. hal., 30.84.

References:

US4083948,1978,A