Thiazolo[4,5-b]pyridin-5(4H)-one, 2-(ethylamino)-7-hydroxy- (9CI) synthesis

1synthesis methods

Product Name:Thiazolo[4,5-b]pyridin-5(4H)-one, 2-(ethylamino)-7-hydroxy- (9CI)
CAS Number:674807-08-0
Molecular formula:C8H9N3O2S
Molecular Weight:211.24

420-04-2 Synthesis

420-04-2
351 suppliers
$15.00/25g

542-85-8
207 suppliers
$52.00/25mL

638-07-3 Synthesis

638-07-3
486 suppliers
$5.00/5G

Thiazolo[4,5-b]pyridin-5(4H)-one, 2-(ethylamino)-7-hydroxy- (9CI)

674807-08-0
9 suppliers
$23.00/1g

Yield:674807-08-0 82%

Reaction Conditions:

Stage #1: CYANAMID;Ethyl isothiocyanatewith potassium hydroxide in ethanol at 20; for 1 h;
Stage #2: ethyl (2-chloroaceto)acetatewith potassium hydroxide in ethanol; for 0.5 h;Reflux;
Stage #3: with hydrogenchloride in ethanol;water at 20; pH=7;regioselective reaction;

References:

Shestopalov, Anatoliy M.;Rodinovskaya, Liudmila A.;Shestopalov, Alexander A. [Tetrahedron,2010,vol. 66,# 46,p. 8945 - 8948] Location in patent:supporting information; experimental part

Thiazolo[4,5-b]pyridin-5(4H)-one, 2-(ethylamino)-7-hydroxy- (9CI) Related Search:

AKOS USSH-4110876