ChemicalBook CAS DataBase List Benzamide, 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)-

Benzamide, 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)- synthesis

4synthesis methods

Product Name:Benzamide, 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)-
CAS Number:680610-54-2
Molecular formula:C10H9F4NO2
Molecular Weight:251.1776

115029-22-6 Synthesis

2-FLUORO-3-(TRIFLUOROMETHYL)BENZOIC ACID

115029-22-6
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16645-06-0
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$306.00/25g

Benzamide, 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)-

680610-54-2
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Yield:680610-54-2 87 %

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine;N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate in dichloromethane at 20 - 30;

Steps:

81.a Step a): Preparation of 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)benzamide

2-fluoro-3-(trifluoromethyl)benzoic acid (5.0g, 24.035mmol), dimethylhydroxylamine hydrochloride (2.8g, 28.841mmol), HATU (13.5g, 35.527mmol), DIPEA (9.3g , 71.925mmol) and dichloromethane (100mL) were added to the reaction flask, stirred at room temperature for 1h. After the reaction, add water (150mL) to quench the reaction, extract with dichloromethane (150mL×3), combine the organic phases, wash with water (200mL×2), saturated brine (200mL) successively, dry over anhydrous sodium sulfate, filter , the filtrate was concentrated under reduced pressure to give 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)benzamide; yield 87.0%;

References:

WO2022/268209,2022,A1 Location in patent:Page/Page column 25; 83

6638-79-5 Synthesis