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5-oxo-1-tosyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carbonitrile synthesis

3synthesis methods
105895-93-0 Synthesis
methyl 2-(N-(3-cyanopropyl)-4-methylphenylsulfonamido)benzoate

105895-93-0
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5-oxo-1-tosyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carbonitrile

68595-19-7
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Yield:68595-19-7 93%

Reaction Conditions:

with potassium tert-butylate in N,N-dimethyl-formamide at 0 - 5; for 2 h;

References:

Tsunoda, Takashi;Tanaka, Akihiro;Mase, Toshiyasu;Sakamoto, Shuichi [Heterocycles,2004,vol. 63,# 5,p. 1113 - 1122]