ChemicalBook CAS DataBase List 2-Oxo-2-[[4-(trifluoroMethyl)phenyl]aMino]acetic Acid

2-Oxo-2-[[4-(trifluoroMethyl)phenyl]aMino]acetic Acid synthesis

2synthesis methods

Product Name:2-Oxo-2-[[4-(trifluoroMethyl)phenyl]aMino]acetic Acid
CAS Number:69066-42-8
Molecular formula:C9H6F3NO3
Molecular Weight:233.14

2-Oxo-2-[[4-(trifluoroMethyl)phenyl]aMino]acetic Acid Ethyl Ester

69066-00-8
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2-Oxo-2-[[4-(trifluoroMethyl)phenyl]aMino]acetic Acid

69066-42-8
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Yield:69066-42-8 500 mg

Reaction Conditions:

with water;lithium hydroxide in tetrahydrofuran at 20; for 2 h;

Steps:

2 Step 2 - Synthesis of [[4-(trifluoromethyl)phenyl]carbamoyl]formic acid (Intermediate 2)

Ethyl [[4-(trifluoro-methyl)phenyl]carbamoyl]formate (600.0 mg, 2.3 mmol, 1.0 equiv) was added to a mixture of THF (15.0 mL) and H₂O (5.0 mL), then LiOH (275.1 mg, 11.5 mmol, 5.0 equiv) was added and the reaction mixture was stirred for 2 h at RT. The reaction mixture was adjusted to pH 5 with concentrated HCl. The aqueous layer was extracted with EtOAc (100 mL x 3). The combined organic layers were dried over anhydrous sodium sulfate and concentrated in vacuo to give [[4-(trifluoromethyl)phenyl]carbamoyl]formic acid (500.0 mg, 2.2 mmol) as a yellow oil. LCMS: Method A, MS-ESI: 232.1 [M-H-].

References:

WO2021/67805,2021,A1 Location in patent:Page/Page column 146

455-14-1
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References

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