1,3-Benzenedicarboxylic acid, 5-[Methyl(Methylsulfonyl)aMino]-,MonoMethyl ester synthesis

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: 95 percent / pyridine / CH₂Cl₂ / 14 h / 23 °C
2.1: NaH / dimethylformamide / 23 °C
2.2: 91 percent / dimethylformamide / 5 h / 23 °C
3.1: 82 percent / NaOH / tetrahydrofuran; methanol; H₂O / 14 h / 23 °C

References:

Ghosh, Arun K.;Kumaragurubaran, Nagaswamy;Hong, Lin;Kulkarni, Sarang S.;Xu, Xiaoming;Chang, Wanpin;Weerasena, Vajira;Turner, Robert;Koelsch, Gerald;Bilcer, Geoffrey;Tang, Jordan [Journal of Medicinal Chemistry,2007,vol. 50,# 10,p. 2399 - 2407]