ChemicalBook CAS DataBase List Oxazole, 2,2'-(1-methyl-2-phenylethylidene)bis[4,5-dihydro-4-(1-methylethyl)-, (4S,4'S)-

Oxazole, 2,2'-(1-methyl-2-phenylethylidene)bis[4,5-dihydro-4-(1-methylethyl)-, (4S,4'S)- synthesis

2synthesis methods

Product Name:Oxazole, 2,2'-(1-methyl-2-phenylethylidene)bis[4,5-dihydro-4-(1-methylethyl)-, (4S,4'S)-
CAS Number:698350-53-7
Molecular formula:C21H30N2O2
Molecular Weight:342.48

100-39-0
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Oxazole, 2,2'-ethylidenebis[4,5-dihydro-4-(1-methylethyl)-, (4S,4'S)-

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Oxazole, 2,2'-(1-methyl-2-phenylethylidene)bis[4,5-dihydro-4-(1-methylethyl)-, (4S,4'S)-

698350-53-7
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Yield:698350-53-7 93%

Reaction Conditions:

Stage #1: (S)-4,5-dihydro-2-{1-[(S)-4,5-dihydro-4-isopropyloxazol-2-yl]ethyl}-4-isopropyloxazolewith lithium tert-butyl in tetrahydrofuran at -78; for 1 h;Inert atmosphere;
Stage #2: benzyl bromide in tetrahydrofuran at -78 - 20;Inert atmosphere;

References:

Qu, Jian-Ping;Xu, Zheng-Hu;Zhou, Jian;Cao, Chun-Li;Sun, Xiu-Li;Dai, Li-Xin;Tang, Yong [Advanced Synthesis and Catalysis,2009,vol. 351,# 3,p. 308 - 312] Location in patent:supporting information; experimental part

2026-48-4
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References