Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid synthesis
- Product Name:Trans-4-(Maleimidomethyl)cyclohexanecarboxylic Acid
- CAS Number:69907-67-1
- Molecular formula:C12H15NO4
- Molecular Weight:237.25
![Cyclohexanecarboxylic acid, 4-[[(3-carboxy-1-oxo-2-propen-1-yl)amino]methyl]-, trans-](/CAS/20200515/GIF/953817-12-4.gif)
953817-12-4
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69907-67-1
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Yield:69907-67-1 7 g
Reaction Conditions:
with sodium acetate;acetic anhydride at 120; for 3 h;Sealed tube;
Steps:
1.B
Step B: The maleamic acid from Step A (36.8 g, 144 mmol) and sodium acetate (13.6 g, 165 mmol) were dissolved in acetic anhydride (368 mL), sealed in a glass reaction vessel, and heated to 120°C for 3 hours. The cooled reaction mixture (a black syrup) was poured onto water (3 L), stirred, and extracted with dichloromethane. The organic layer was dried over Na2504, filtered over a sintered glass funnel, and the clear filtrate evaporated and dried under high vacuum giving the title compound as a yellow solid (7.00 g, 20%). 1H NMR (300 MHz, CDC13) 3 6.73 (s, 2H), 3.40 (d, 2H, J = 7 Hz), 2.28 (m, 1H), 2.06 (m, 2H), 1.75 (m, 3H), 1.42 (m, 2H), 1.03 (m, 2H).
References:
WO2015/31396,2015,A1 Location in patent:Paragraph 00103
108-31-6
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1197-18-8
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69907-67-1
79 suppliers
$29.00/250mg
69907-68-2
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69907-67-1
79 suppliers
$29.00/250mg
1197-18-8
825 suppliers
$10.00/5g
69907-67-1
79 suppliers
$29.00/250mg