7,9-difluoro-2,3,4,5-tetrahydro-1-benzoxepin-5-one synthesis

1synthesis methods

Product Name:7,9-difluoro-2,3,4,5-tetrahydro-1-benzoxepin-5-one
CAS Number:127557-05-5
Molecular formula:C10H8F2O2
Molecular Weight:198.17

367-27-1 Synthesis

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7,9-difluoro-2,3,4,5-tetrahydro-1-benzoxepin-5-one

127557-05-5
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: K₂CO₃, KI / acetone / 72 h / Heating
2: NaOH / ethanol; H₂O / Heating
3: 6 percent / polyphosphoric acid / 1 h / 85 °C

References:

Freedman, Jules;Stewart, Kenneth T. [Journal of Heterocyclic Chemistry,1989,vol. 26,p. 1547 - 1554]