ChemicalBook CAS DataBase List 7-Aza-spiro[3.5]nonane

7-Aza-spiro[3.5]nonane synthesis

3synthesis methods

Product Name:7-Aza-spiro[3.5]nonane
CAS Number:766-34-7
Molecular formula:C8H15N
Molecular Weight:125.21

203661-69-2 Synthesis

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

203661-69-2
164 suppliers
$8.00/250mg

766-34-7
38 suppliers
$156.00/50mg

Yield:766-34-7 93%

Reaction Conditions:

with hydrazine hydrate;sodium hydroxide at 200; for 4 h;Reflux;

Steps:

12.3 7-azaspiro[3.5]nonane

The 20-3 (5.6g, 23.4mmol), hydrazine hydrate (8.10g, 161.8mmol) and NaOH (5.85g, 146.4mmol) was dissolved in three polyethylene glycol (100mL), was heated under reflux for 1 hour.Condenser is then removed, and the temperature was heated to 200 deg.] C for 3 hours.After cooling, water was added and 100mL of diethyl ether mixture, liquid separation, extraction, the organic phase was dried and concentrated by silica gel column chromatography to give 20-4 (2.8 g, 93%).

References:

CN103635456,2016,B Location in patent:Paragraph 0387-0389

159635-49-1 Synthesis

tert-Butyl 4-methylenepiperidine-1-carboxylate

159635-49-1
247 suppliers
$5.00/250mg

766-34-7
38 suppliers
$156.00/50mg

References

396653-31-9 Synthesis

tert-butyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

396653-31-9
14 suppliers
inquiry

766-34-7
38 suppliers
$156.00/50mg

References