ChemicalBook CAS DataBase List 7-Benzofurancarboxaldehyde (9CI)

7-Benzofurancarboxaldehyde (9CI) synthesis

10synthesis methods

Product Name:7-Benzofurancarboxaldehyde (9CI)
CAS Number:95333-14-5
Molecular formula:C9H6O2
Molecular Weight:146.14

209256-55-3
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$157.00/250mg

95333-14-5
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$48.00/100mg

Yield:95333-14-5 80%

Reaction Conditions:

Stage #1: benzofuran-7-ylmethanolwith oxalyl dichloride;dimethyl sulfoxide in Dichlorodifluoromethane at -78; for 0.5 h;
Stage #2: with triethylamine in dichloromethane at -78 - 20;

Steps:

4.5

DMSO (2.87 ml, 40 mmol) was added slowly to a -78°C solution of oxalyl chloride in methylene chloride (20 ml of 2 M, 40 mmol). To this solution was added slowly a solution of benzofuran-7-methanol (4.03 g, 27 mmol) in methylene chloride, and the mixture was stirred 30 min at-78°C. Triethyl amine (30 ml) was added slowly to the reaction mixture, which was then allowed to warm to room temperature. The mixture was diluted with methylene chloride and washed with water and then with brine. The organic layer was concentrated in vacuo to an oil (3.16 g, 80%).

References:

EP1027043,2004,B1 Location in patent:Page/Page column 19