7-Benzyl-4,7-diazaspiro[2.5]octane synthesis
- Product Name:7-Benzyl-4,7-diazaspiro[2.5]octane
- CAS Number:1222106-45-7
- Molecular formula:C13H18N2
- Molecular Weight:202.3
1222106-43-5
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1222106-45-7
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$139.00/100mg
Yield:1222106-45-7 100%
Reaction Conditions:
with sodium tetrahydroborate;boron trifluoride diethyl etherate in tetrahydrofuran at 0; for 20 h;Reflux;Green chemistry;
Steps:
3 Preparation of a compound of formula I
The compound of formula V (804.9 g, 3.49 mol) was suspended in tetrahydrofuran (3 L), sodium borohydride (1056 g, 27.9 mol) was added, cooled to 0 °C in a cold bath, and boron trifluoride diethyl ether (2970 g) was added dropwise. , 20.94mol), after completion, heated reflux reaction for 20h,The reaction solution was cooled to 0 to 10 °C, and 6N aqueous hydrochloric acid solution (6.4 L) was added dropwise to the reaction system, and the temperature was controlled at 30 °C, and the reaction solution was cooled to about 5 °C with a mass fraction of 50% NaOH. The aqueous solution is adjusted to a pH of 9, dichloromethane (3.0 LX 3) is extracted, and the organic phase is combined. Drying to give a brown oil of 706.0 g, the compound of formula I, The yield is 100%.
References:
CN108863958,2018,A Location in patent:Paragraph 0073; 0083; 0084; 0085
6436-90-4
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1222106-45-7
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$139.00/100mg
84677-06-5
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1222106-45-7
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$139.00/100mg
100-46-9
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1222106-45-7
42 suppliers
$139.00/100mg