ChemicalBook CAS DataBase List 7-Bromo-1H-indazole

7-Bromo-1H-indazole synthesis

4synthesis methods

Product Name:7-Bromo-1H-indazole
CAS Number:53857-58-2
Molecular formula:C7H5BrN2
Molecular Weight:197.03

Diazene, 1-(2-bromo-6-methylphenyl)-2-[(1,1-dimethylethyl)thio]-

845751-60-2
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53857-58-2
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Yield:53857-58-2 96%

Reaction Conditions:

with potassium tert-butylate in dimethyl sulfoxide at 20; for 2 h;

Steps:

1.4

A solution of (2-bromo-6-methylphenylazo)-t-butylsulfide (2b; 880 mg, 3.06 mmol) in 10 mL dry DMSO was added dropwise to a solution of potassium t-butoxide (3.44 g, 30.6 mmol) in 25 mL dry DMSO under Ar. The reaction mixture was stirred at room temp for 2 hr, then poured into 150 g ice and 150 mL 2 N HCl solution. The mixture was extracted with ether (2?150 mL). The combined ethereal extracts were washed with brine and dried over MgSO4. Evaporation of the solvent afforded 581 mg (96%) of 3 as a beige solid.

References:

US2004/110815,2004,A1 Location in patent:Page/Page column 19

53848-17-2 Synthesis