ChemicalBook CAS DataBase List 7-bromo-2,3-dihydro-1,4-benzodioxin-6-amine

7-bromo-2,3-dihydro-1,4-benzodioxin-6-amine synthesis

4synthesis methods

Product Name:7-bromo-2,3-dihydro-1,4-benzodioxin-6-amine
CAS Number:368839-12-7
Molecular formula:C8H8BrNO2
Molecular Weight:230.06

22013-33-8 Synthesis

22013-33-8
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7-bromo-2,3-dihydro-1,4-benzodioxin-6-amine

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Yield:368839-12-7 93%

Reaction Conditions:

with N-Bromosuccinimide;sulfuric acid in tetrahydrofuran at -78 - 20; for 1 h;

Steps:

4.a

A solution of 2, 3-dihydro-benzo [1, 4] dioxin-6-ylamine (1 g, 6.6 mmol) in tetrahydrofuran (15 ml) was cooled to-78 deg C then treated with 1 drop of concentrated sulphuric acid followed by N-bromosuccinimide (1.2g, 6.6. mmol). The mixture was allowed to warm to room temperature over 1 hour then evaporated. The residue was dissolved in ether, washed with water then brine, dried and evaporated to afford an oil (1. 4 g, 93%). MS (+ve ion electrospray) m/z 231 (MH+).

References:

WO2004/2490,2004,A2 Location in patent:Page/Page column 48

6-BROMO-7-NITRO-2,3-DIHYDRO-1,4-BENZODIOXINE

59820-92-7
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368839-12-7
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References

62140-78-7 Synthesis

7-NITRO-2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YLAMINE

62140-78-7
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368839-12-7
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References

52287-51-1 Synthesis

52287-51-1
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368839-12-7
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References