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ChemicalBook CAS DataBase List 7-BroMo-2,3-dihydroquinolin-4(1H)-one
114417-34-4

7-BroMo-2,3-dihydroquinolin-4(1H)-one synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 5 steps
1: AcOH / 22 h / Heating
2: pyridine / 0.33 h / Heating
3: aq. HCl / dioxane / 3 h / Heating
4: 1.) PCl5, 2.) AlCl3 / 1.) benzene, from 5 deg C to 23 deg C, 30 min, 2.) benzene 15-20 deg C, 3.5 h
5: 30 percent / gl. AcOH, aq. HCl / 3.5 h / Heating

References:

Werbel, L. M.;Kesten, S. J.;Turner, W. R. [European Journal of Medicinal Chemistry,1993,vol. 28,# 11,p. 837 - 852]

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