ChemicalBook CAS DataBase List 7-broMo-2-(chloroMethyl)H-iMidazo[1,2-a]pyridine

7-broMo-2-(chloroMethyl)H-iMidazo[1,2-a]pyridine synthesis

3synthesis methods

Product Name:7-broMo-2-(chloroMethyl)H-iMidazo[1,2-a]pyridine
CAS Number:1019023-07-4
Molecular formula:C8H6BrClN2
Molecular Weight:245.5

1187236-21-0 Synthesis

IMidazo[1,2-a]pyridine-2-Methanol, 7-broMo-

1187236-21-0
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7-broMo-2-(chloroMethyl)H-iMidazo[1,2-a]pyridine

1019023-07-4
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$497.56/5MG

Yield:1019023-07-4 0.325 mg

Reaction Conditions:

with thionyl chloride in dichloromethane at 0 - 20; for 2 h;

Steps:

57.3 Step 3
Preparation of 7-Bromo-2-chloromethyl-imidazo[1,2-a]pyridine

Step 3
Preparation of 7-Bromo-2-chloromethyl-imidazo[1,2-a]pyridine
To a stirred solution of 7-Bromo-imidazo[1,2-a]pyridin-2-yl)-methanol (0.340 g, 1.497 mmol) in CH₂Cl₂ (5 mL) is added SOCl₂ (0.11 mL, 1.497 mmol) drop wise at 0° C. then stirred at room temperature for 2 hours.
The reaction mixture is diluted with saturated sodium bicarbonate and extracted with CH₂Cl₂.
The organic layer dried over sodium sulfate, and solvent is evaporated under vacuum to afford the title compound (0.325 mg).
¹H-NMR (400 MHz, DMSO-d₆) δ: 4.84 (s, 2H), 7.07-7.09 (dd, J1=1.92 Hz, J2=7.16 Hz), 7.85 (d, J=1.48 Hz, 1H), 8.03 (s, 1H), 8.50 (d, J=7.24 Hz, 1H). LC-MS (m/z): [M+H]=247.0.

References:

US2013/237502,2013,A1 Location in patent:Paragraph 0384

84249-14-9 Synthesis

84249-14-9
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1019023-07-4
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$497.56/5MG

References

IMidazo[1,2-a]pyridine-2-carboxylic acid, 7-broMo-, ethyl ester

1187236-18-5
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$59.00/250mg

1019023-07-4
9 suppliers
$497.56/5MG

References