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7-BROMO-6-FLUOROPYRIDO[3,2-D]PYRIMIDIN-4(3H)-ONE synthesis

5synthesis methods
6-AMINO-7-BROMOPYRIDO[3,2-D]PYRIMIDIN-4(3H)-ONE

267243-48-1
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7-BROMO-6-FLUOROPYRIDO[3,2-D]PYRIMIDIN-4(3H)-ONE

267243-49-2
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Yield:267243-49-2 54%

Reaction Conditions:

with sodium nitrite at -20 - -10;Fluorination;

References:

Smaill, Jeff B.;Rewcastle, Gordon W.;Loo, Joseph A.;Greis, Kenneth D.;Chan, O. Helen;Reyner, Eric L.;Lipka, Elke;Showalter, H. D. Hollis;Vincent, Patrick W.;Elliott, William L.;Denny, William A. [Journal of Medicinal Chemistry,2000,vol. 43,# 7,p. 1380 - 1397]

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