ChemicalBook CAS DataBase List 7-bromo-benzo[c][1,2,5]thiadiazole-4-carbaldehyde

7-bromo-benzo[c][1,2,5]thiadiazole-4-carbaldehyde synthesis

7synthesis methods

Product Name:7-bromo-benzo[c][1,2,5]thiadiazole-4-carbaldehyde
CAS Number:1071224-34-4
Molecular formula:C7H3BrN2OS
Molecular Weight:243.08

4-BroMo-7-(dibroMoMethyl)benzo[c][1,2,5]thiadiazole

1239277-96-3
21 suppliers
$45.00/10mg

7-bromo-benzo[c][1,2,5]thiadiazole-4-carbaldehyde

1071224-34-4
106 suppliers
$36.97/25G

Yield:1071224-34-4 80%

Reaction Conditions:

with formic acid at 120; for 24 h;

Steps:

1 Synthesis of Br-CHO:

Intermediate 3 (30.74 g, 79.45 mmol, 1.0 equivalent) and formic acid (100 mL) were sequentially added to a dry three-necked flask equipped with magnetic stirring, placed in an oil bath, and heated to 120°C.After 24 hours, the reaction was monitored by thin layer chromatography until the reaction was complete.The resulting mixture was cooled to room temperature, quenched by adding water and stirred for 1 hour.The resulting mixture was concentrated in vacuum, the residue was washed three times with water, and finally dried in a vacuum drying oven to obtain 15.45 g of brown solid compound with a yield of 80%

References:

CN111471043,2020,A Location in patent:Paragraph 0050; 0051; 0055