7-broMoquinolin-3-aMine synthesis
- Product Name:7-broMoquinolin-3-aMine
- CAS Number:1266322-58-0
- Molecular formula:C9H7BrN2
- Molecular Weight:223.07
1375108-38-5
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1266322-58-0
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Yield: 97%
Reaction Conditions:
with hydrazine hydrate in ethanol for 1 h;Reflux;
Steps:
A.A87.3 Preparation of intermediate 397
A suspension of intermediate 396 ( 14 g, 38.5 mmol) in ethanol ( 1 50 mL) was treated with NH2 H2.H2O (4.5 g, 76.9 mmol ) and was re fluxed for l hour. The mixture was al lowed to cool and filtered. The filtrate was col lected and evaporated to obtain intermediate 397 (8.6 g, 94% yield).
References:
JANSSEN PHARMACEUTICA NV;WU, Tongfei;BREHMER, Dirk;BEKE, Lijs;BOECKX, An;DIELS, Gaston, Stanislas, Marcella;GILISSEN, Ronaldus, Arnodus, Hendrika, Joseph;LAWSON, Edward, Charles;PANDE, Vineet;PARADE, Marcus, Cornelis, Bernardus, Catharina;SCHEPENS, Wim, Bert, Griet;THURING, Johannes, Wilhelmus, John, F;VIELLEVOYE, Marcel;SUN, Weimei;MEERPOEL, Lieven WO2017/32840, 2017, A1 Location in patent:Page/Page column 265; 266
59278-65-8
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1266322-58-0
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$52.00/100mg
135484-83-2
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1266322-58-0
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946122-05-0
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1266322-58-0
38 suppliers
$52.00/100mg