![](/CAS/GIF/88525-51-3.gif)
7-CHLORO-1,3-BENZODIOXOLE-5-CARBALDEHYDE synthesis
- Product Name:7-CHLORO-1,3-BENZODIOXOLE-5-CARBALDEHYDE
- CAS Number:88525-51-3
- Molecular formula:C8H5ClO3
- Molecular Weight:184.58
![BROMODICHLOROMETHANE](/CAS/20180808/GIF/75-27-4.gif)
75-27-4
111 suppliers
$28.30/1mL
![3-CHLORO-4,5-DIHYDROXYBENZALDEHYDE](/CAS/GIF/34098-18-5.gif)
34098-18-5
39 suppliers
inquiry
![7-CHLORO-1,3-BENZODIOXOLE-5-CARBALDEHYDE](/CAS/GIF/88525-51-3.gif)
88525-51-3
28 suppliers
$75.00/50mg
Yield:88525-51-3 70%
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide at 60;
Steps:
6.b; 18 7-Chlorobenzo[d][1,3]dioxole-5-carbaldehyde
To a solution of 3-chloro-4,5-dihydroxybenzaldehyde (8.0 g, 46 mmol) and BrClCH2 (23.9 g, 185 mmol) in dry DMF (100 mL) was added Cs2CO3 (25 g, 190 mmol).
The mixture was stirred at 60° C. overnight and was then poured into water.
The resulting mixture was extracted with EtOAc (50 mL*3).
The combined extracts were washed with brine (100 mL), dried over Na2SO4 and concentrated under reduced pressure to afford 7-chlorobenzo[d][1,3]dioxole-5-carbaldehyde (6.0 g, 70%).
1H NMR (400 MHz, CDCl3) δ 9.74 (s, 1H), 7.42 (d, J=0.4 Hz, 1H), 7.26 (d, J=3.6 Hz, 1H), 6.15 (s, 2H)
References:
US2015/231142,2015,A1 Location in patent:Paragraph 1133; 1585
![3-CHLORO-4,5-DIHYDROXYBENZALDEHYDE](/CAS/GIF/34098-18-5.gif)
34098-18-5
39 suppliers
inquiry
![7-CHLORO-1,3-BENZODIOXOLE-5-CARBALDEHYDE](/CAS/GIF/88525-51-3.gif)
88525-51-3
28 suppliers
$75.00/50mg
![5-CHLOROVANILLIN](/CAS/GIF/19463-48-0.gif)
19463-48-0
105 suppliers
$24.00/1g
![7-CHLORO-1,3-BENZODIOXOLE-5-CARBALDEHYDE](/CAS/GIF/88525-51-3.gif)
88525-51-3
28 suppliers
$75.00/50mg