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7-Chloro-2-chloroMethyl-1H-quinazolin-4-one synthesis

3synthesis methods
-

Yield:730951-40-3 78%

Reaction Conditions:

Stage #1: chloroacetonitrilewith natrium in methanol at 25; for 0.666667 h;Inert atmosphere;
Stage #2: 2-Amino-4-chlorobenzoic acid in methanol at 25; for 4 h;Inert atmosphere;

References:

Li, Hong-Ze;He, Hai-Yun;Han, Yuan-Yuan;Gu, Xin;He, Lin;Qi, Qing-Rong;Zhao, Ying-Lan;Yang, Li [Molecules,2010,vol. 15,# 12,p. 9473 - 9485] Location in patent:experimental part