7-Chloro-2H-chromen-2-one synthesis

12synthesis methods

Product Name:7-Chloro-2H-chromen-2-one
CAS Number:19063-54-8
Molecular formula:C9H5ClO2
Molecular Weight:180.59

108-43-0 Synthesis

108-43-0
294 suppliers
$13.00/5g

471-25-0
226 suppliers
$10.00/1g

19063-54-8
23 suppliers
$200.00/100mg

Yield:19063-54-8 69%

Reaction Conditions:

with trifluoroacetic acid in chlorobenzene at 100; for 1 h;Inert atmosphere;

Steps:

General Procedure forthe Synthesis of Coumarin Derivatives.

General procedure: A mixture of Phenol derivatives (1) (1.0 mmol), trifluoromethanesulfonic acid (1.0 mmol) and propiolic acid (2a) (0.5 mmol) in PhCl (3.0 mL) was stirred at 100 °C for 1 h. After completion of reaction as indicated by TLC, the reaction mixture was poured into H₂O, neutralized with NaHCO₃solution and extracted CH₂Cl₂. The organic layer was washed with 2M NaOH, dried over anhydrous MgSO₄. The solvent was removed in vaccum, and the products were purified by silica gel columnchromatography (EtOAc-Hex) to give the desired product 3.

References:

Choi, Hyuck;Kim, Jaehyun;Lee, Kooyeon [Tetrahedron Letters,2016,vol. 57,# 32,p. 3600 - 3603] Location in patent:supporting information

2420-26-0 Synthesis