7-chloroisoquinoline-1-carboxylic acid synthesis
- Product Name:7-chloroisoquinoline-1-carboxylic acid
- CAS Number:552850-71-2
- Molecular formula:C10H6ClNO2
- Molecular Weight:207.61
70810-24-1
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Yield:-
Steps:
Multi-step reaction with 2 steps
1.1: 1,5-bis-(diphenylphosphino)pentane; N,N,N,N,-tetramethylethylenediamine; palladium diacetate / toluene / 150 °C / Inert atmosphere
2.1: sodium hydroxide / 80 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
References:
St. Laurent, Denis R.;Serrano-Wu, Michael H.;Belema, Makonen;Ding, Min;Fang, Hua;Gao, Min;Goodrich, Jason T.;Krause, Rudolph G.;Lemm, Julie A.;Liu, Mengping;Lopez, Omar D.;Nguyen, Van N.;Nower, Peter T.;O'Boyle, Donald R.;Pearce, Bradley C.;Romine, Jeffrey L.;Valera, Lourdes;Sun, Jin-Hua;Wang, Ying-Kai;Yang, Fukang;Yang, Xuejie;Meanwell, Nicholas A.;Snyder, Lawrence B. [Journal of Medicinal Chemistry,2014,vol. 57,# 5,p. 1976 - 1994]
1368066-86-7
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552850-71-2
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