ChemicalBook CAS DataBase List 7-FLUORO-1-TETRALONE

7-FLUORO-1-TETRALONE synthesis

11synthesis methods

Product Name:7-FLUORO-1-TETRALONE
CAS Number:2840-44-0
Molecular formula:C10H9FO
Molecular Weight:164.18

7-FLUORO-1-TETRALONE is an organic intermediate, which can be prepared from fluoro - benzene through a four-step reaction.

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Yield:-

Reaction Conditions:

aluminium trichloride in hydrogenchloride;carbon disulfide;(2S)-N-methyl-1-phenylpropan-2-amine hydrate;

Steps:

13.c c)

To a mixture of aluminum chloride (66 g, 0.50 mol) in carbon disulfide (600 mL) was added dropwise a solution of 4-(4-fluorophenyl)butyryl chloride (75.3 g, 0.37 mole) in carbon disulfide (260 mL) keeping the internal temperature below 10° C. After refluxing for 0.5 h, the reaction mixture was poured into a mixture of concentrated HCl (50 mL) and ice water (800 mL). The mixture was filtered and extracted with diethyl ether. The diethyl ether extracts were dried and concentrated it7 vacuo to give crude 7-fluoro-1-tetralone. Vacuum distillation gave pure 7-fluoro-1-tetralone b.p., 83° C. at 0.3 mm Hg which solidified to a white solid (94%). m.p., 62°-64° C. (lit, J. Am. Chem. Soc., 89, 386, 1967, m.p., 63.5°-65.0° C.);

References:

US5872118,1999,A