7-fluoro-2-oxo-1H-quinoline-3-carbaldehyde synthesis

Yield:-

Steps:

Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 3 h / 0 - 25 °C
2: trichlorophosphate / 16 h / 0 - 80 °C
3: sodium acetate; acetic acid / 3 h / 110 °C

References:

Reddy, B. K. Kishore;Landge, Sudhir;Ravishankar, Sudha;Patil, Vikas;Shinde, Vikas;Tantry, Subramanyam;Kale, Manoj;Raichurkar, Anandkumar;Menasinakai, Sreenivasaiah;Mudugal, Naina Vinay;Ambady, Anisha;Ghosh, Anirban;Tunduguru, Ragadeepthi;Kaur, Parvinder;Singh, Ragini;Kumar, Naveen;Bharath, Sowmya;Sundaram, Aishwarya;Bhat, Jyothi;Sambandamurthy, Vasan K.;Bj?rkelid, Christofer;Jones, T. Alwyn;Das, Kaveri;Bandodkar, Balachandra;Malolanarasimhan, Krishnan;Mukherjee, Kakoli;Ramachandran, Vasanthi [Antimicrobial Agents and Chemotherapy,2014,vol. 58,# 6,p. 3312 - 3326]