7-iodo-9H-fluoren-2-aMine synthesis

Yield:34172-48-0 97%

Reaction Conditions:

with tin(II) chloride dihdyrate in ethanol; for 18 h;Reflux;

Steps:

36 Synthesis of compound 36

A mixture of 7-iodo-2-nitrofluorene (1.7 g, 5 mmol; Marhevka, V.C. , et al., 1985, J. Med.Chem., 28, 18.), SnCl2 x 2H2O (5.6 g, 25 mmol) in dry EtOH (100 ml) was refluxed for 18 h. The cold mixture was poured to H20 (70 ml), neutralized with solidNaHC03, extracted with CH2CI2 (200 ml and 2 x 100 ml) and dried with Na2S04. Yield: 1.5 g (97%).

References:

JP2017/520516,2017,A Location in patent:Paragraph 0129