7-Isoquinolinesulfonamide, 1-chloro- synthesis
- Product Name:7-Isoquinolinesulfonamide, 1-chloro-
- CAS Number:223671-78-1
- Molecular formula:C9H7ClN2O2S
- Molecular Weight:242.68
215453-51-3
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223671-78-1
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Yield:223671-78-1 37 mg
Reaction Conditions:
Stage #1: 7-bromo-1-chloroisoquinolinewith n-butyllithium in tetrahydrofuran;diethyl ether;hexane at -78; for 0.0833333 h;
Stage #2: with sulfuryl dichloride in tetrahydrofuran;diethyl ether;hexane at -25 - 23; for 3 h;
Stage #3: with ammonia in tetrahydrofuran;diethyl ether;hexane;Further stages.;
References:
Fish, Paul V.;Barber, Christopher G.;Brown, David G.;Butt, Richard;Collis, Michael G.;Dickinson, Roger P.;Henry, Brian T.;Horne, Valerie A.;Huggins, John P.;King, Elizabeth;O'Gara, Margaret;McCleverty, Dawn;McIntosh, Fraser;Phillips, Christopher;Webster, Robert [Journal of Medicinal Chemistry,2007,vol. 50,# 10,p. 2341 - 2351]
223671-15-6
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223671-78-1
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