7-METHOXY-4-(TRIFLUOROMETHYL)COUMARIN synthesis
- Product Name:7-METHOXY-4-(TRIFLUOROMETHYL)COUMARIN
- CAS Number:575-04-2
- Molecular formula:C11H7F3O3
- Molecular Weight:244.17
575-03-1
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77-78-1
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575-04-2
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$135.00/50mg
Yield:575-04-2 97.8%
Reaction Conditions:
with potassium carbonate in acetone; for 8 h;Reflux;
Steps:
3.1.3. Synthesis of 4-Trifluoromethyl-7-methoxycoumarin (2)
Dimethyl sulfate (2.5 g, 20 mmol) was added dropwise to the suspension of compound 1 (5.8 g,25 mmol) and anhydrous K2CO3 (4.1 g, 30 mmol) in 66 mL of acetone with stirring. Then the mixturewas heated to reflux for 8 h. After K2CO3 was filtered out, the filtrate was rotary evaporated to 1/3 ofthe total volume. Then the residue was allowed to cool to room temperature until a white solidprecipitated. The solid product was filtered out and washed with cold water to neutral pH to getcompound 2. Yield 97.8%, m.p. 110-112° C (lit. 111-112 °C) [55].
References:
Qiao, Lili;Hao, Shuanghong [Molecules,2018,vol. 23,# 3,art. no. 600]
531-59-9
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2923-18-4
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$5.00/10g
575-04-2
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$135.00/50mg
108-46-3
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$10.00/10g
575-04-2
75 suppliers
$135.00/50mg
31083-16-6
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575-04-2
75 suppliers
$135.00/50mg