ChemicalBook CAS DataBase List 7-METHOXY-4-(TRIFLUOROMETHYL)COUMARIN

7-METHOXY-4-(TRIFLUOROMETHYL)COUMARIN synthesis

8synthesis methods

Product Name:7-METHOXY-4-(TRIFLUOROMETHYL)COUMARIN
CAS Number:575-04-2
Molecular formula:C11H7F3O3
Molecular Weight:244.17

575-03-1 Synthesis

575-03-1
189 suppliers
$12.00/250mg

77-78-1
298 suppliers
$22.00/25g

575-04-2
69 suppliers
$135.00/50mg

Yield:575-04-2 97.8%

Reaction Conditions:

with potassium carbonate in acetone; for 8 h;Reflux;

Steps:

3.1.3. Synthesis of 4-Trifluoromethyl-7-methoxycoumarin (2)

Dimethyl sulfate (2.5 g, 20 mmol) was added dropwise to the suspension of compound 1 (5.8 g,25 mmol) and anhydrous K2CO3 (4.1 g, 30 mmol) in 66 mL of acetone with stirring. Then the mixturewas heated to reflux for 8 h. After K2CO3 was filtered out, the filtrate was rotary evaporated to 1/3 ofthe total volume. Then the residue was allowed to cool to room temperature until a white solidprecipitated. The solid product was filtered out and washed with cold water to neutral pH to getcompound 2. Yield 97.8%, m.p. 110-112° C (lit. 111-112 °C) [55].

References:

Qiao, Lili;Hao, Shuanghong [Molecules,2018,vol. 23,# 3,art. no. 600]

150-19-6 Synthesis