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7-methylthieno[3,2-d]pyrimidin-4-amine synthesis
- Product Name:7-methylthieno[3,2-d]pyrimidin-4-amine
- CAS Number:1301212-43-0
- Molecular formula:C7H7N3S
- Molecular Weight:165.22
![4-CHLORO-7-METHYLTHIENO[3,2-D]PYRIMIDINE](/CAS/GIF/175137-21-0.gif)
175137-21-0
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![7-methylthieno[3,2-d]pyrimidin-4-amine](/CAS/20180601/GIF/1301212-43-0.gif)
1301212-43-0
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Yield:1301212-43-0 78%
Reaction Conditions:
with ammonium hydroxide in butan-1-ol at 90; for 4 h;Sealed tube;
Steps:
28.A
EXAMPLE 28; (3R,4R)-N-(7-Methylthieno[3,2-d]pyrimidin-4-yl)-4'H-l- azaspiro[bicyclo[2.2.1 heptane-3, 5 '-οχαζο J -2 '-amine; Step A: 7-Methylthieno[3,2-d]pyrim; In a sealed tube was added 4-chloro-7-methylthieno[3,2-d]pyrimidine (2.0 g, 10.83 mmol) and ammonium hydroxide (12.65 mmol, 325 mmol) in butanol (7ml). The reaction was heated to 90C for 4 hours and then cooled to room temperature. The resulting white precipitate was collected to give 7-methylthieno[3,2-d]pyrimidin 4-amine (1.4 g, 78% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 8.41 (1 H, s), 7.74 (1 H, s), 7.34 (2 H, s), 2.34 (3 H, d, J=1.00 Hz).
References:
WO2011/56503,2011,A1 Location in patent:Page/Page column 68