7-NITRO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE synthesis

3synthesis methods

Product Name:7-NITRO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE
CAS Number:22246-45-3
Molecular formula:C10H10N2O3
Molecular Weight:206.2

1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one

4424-80-0
143 suppliers
$25.00/1g

7-NITRO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE

22246-45-3
22 suppliers
$400.00/1g

Yield: 78%

Reaction Conditions:

with sulfuric acid;nitric acid at 0; for 0.5 h;

Steps:

8.3 Step three:7-nitro-1,3,4,5-tetrahydro-2H-benzene [b] azepan-2-one
At 0 ,1,3,4,5-tetrahydro-2H-benzene [b] azepan-2-one(2.10 g, 13 mmol) was dissolved in concentrated sulfuric acid (10 mL)Then concentrated nitric acid (1.1 mL, 15.6 mmol) was added dropwise to the reaction solution,Reaction for half an hour.After completion of the reaction, the reaction solution was poured into ice water,filter,The solid was washed with petroleum ether / ethyl acetate (40 mL, v / v: 1: 1)Dry in the air7-nitro-1,3,4,5-tetrahydro-2H-benzene [b] azepan-2-one(2.10 g) in a yield of 78%.

References:

Shanghai Hansoh BioMedical Co.,Ltd.;Jiangsu Hansoh Pharmaceutical Group Co., Ltd.;Zhao, Zhiming;Lin, Sheng;Huang, Zhiqiang;Yu, Hongping;Xu, Yaochang;Pan, Zhongzong CN106349233, 2017, A Location in patent:Paragraph 0295; 0302; 0303; 0304; 0305

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
0 suppliers
inquiry

22246-45-3
22 suppliers
$400.00/1g

References

4424-80-0
143 suppliers
$25.00/1g

22246-45-3
22 suppliers
$400.00/1g

8-NITRO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE

22246-79-3
30 suppliers
$169.52/250mg

References

7-NITRO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE Related Search:

2,3,4,5-Tetrahydro-1H-benzo[b]azepine