1H-Pyrrolo[2,3-c]pyridine-3-acetic acid, 4-Methoxy-7-(3-Methyl-1H-1,2,4-triazol-1-yl)-α-oxo-, Methyl ester synthesis

15synthesis methods

Product Name:1H-Pyrrolo[2,3-c]pyridine-3-acetic acid, 4-Methoxy-7-(3-Methyl-1H-1,2,4-triazol-1-yl)-α-oxo-, Methyl ester
CAS Number:701214-00-8
Molecular formula:C14H13N5O4
Molecular Weight:315.29

5781-53-3 Synthesis

5781-53-3
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1H-Pyrrolo[2,3-c]pyridine, 4-Methoxy-7-(3-Methyl-1H-1,2,4-triazol-1-yl)-

676491-46-6
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1H-Pyrrolo[2,3-c]pyridine-3-acetic acid, 4-Methoxy-7-(3-Methyl-1H-1,2,4-triazol-1-yl)-α-oxo-, Methyl ester

701214-00-8
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Yield:701214-00-8 76%

Reaction Conditions:

Stage #1: 4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridinewith pyridine;isopropylmagnesium chloride in 2-methyltetrahydrofuran at -25 - -10;Large scale;
Stage #2: monomethyl oxalyl chloride in 2-methyltetrahydrofuran at -25 - -10; for 3 h;Large scale;

References:

Fox, Richard J.;Tripp, Jonathan C.;Schultz, Mitchell J.;Payack, Joseph F.;Fanfair, Dayne D.;Mudryk, Boguslaw M.;Murugesan, Saravanababu;Chen, Chung-Pin H.;La Cruz, Thomas E.;Ivy, Sabrina E.;Broxer, Sévrine;Cullen, Ryan;Erdemir, Deniz;Geng, Peng;Xu, Zhongmin;Fritz, Alan;Doubleday, Wendel W.;Conlon, David A. [Organic Process Research and Development,2017,vol. 21,# 8,p. 1095 - 1109]

5781-53-3 Synthesis

5781-53-3
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701214-00-8
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References

676491-46-6
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$130.00/50mg

4755-77-5 Synthesis