ChemicalBook CAS DataBase List cis-3-[4-(1,1-DiMethylheptyl)-2-(phenylMethoxy)phenyl]-cyclohexanol

cis-3-[4-(1,1-DiMethylheptyl)-2-(phenylMethoxy)phenyl]-cyclohexanol synthesis

10synthesis methods

Product Name:cis-3-[4-(1,1-DiMethylheptyl)-2-(phenylMethoxy)phenyl]-cyclohexanol
CAS Number:70434-49-0
Molecular formula:C28H40O2
Molecular Weight:408.62

70120-09-1 Synthesis

α,α-DiMethyl-3-(phenylMethoxy)benzeneacetaldehyde

70120-09-1
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$498.18/5MG

cis-3-[4-(1,1-DiMethylheptyl)-2-(phenylMethoxy)phenyl]-cyclohexanol

70434-49-0
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Yield:-

Steps:

Multi-step reaction with 7 steps
1: 57 percent / DMSO, NaOH / 4 h / 15 °C
2: 78 percent / H₂ / 10percent Pd/C / ethanol / 13 h / 2585.7 Torr
3: 100 percent / Br₂ / CCl₄ / 0.25 h / 30 °C
4: 1.) KH / 1.) DMF, -18 deg C, 15 min, 2.) 25 deg C, 30 min
5: Mg / tetrahydrofuran / 20 h / Heating
6: CuI / tetrahydrofuran / 0.5 h / -3 °C
7: 51 percent / NaBH₄ / methanol; tetrahydrofuran / 1 h / -40 °C

References:

Melvin, Lawrence S.;Johnson, M. Ross;Harbert, Charles A.;Milne, George M.;Weissman, Albert [Journal of Medicinal Chemistry,1984,vol. 27,# 1,p. 67 - 71]

70434-13-8 Synthesis